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A2A receptor activation upregulates vascular endothelial growth factor (VEGF), promotes angiogenesis in dermal microvasculature, stimulates fibroblast migration and proliferation, and suppresses inflammatory cytokine release
Insulin-dependent glucose uptake by adipose tissue and skeletal muscle is likewise reduced, redirecting glucose to the liver where it fuels DNL by activating the carbohydrate response element-binding protein (ChREBP), a master transcriptional regulator of lipogenic pathway proteins (53)
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J Biol Chem 229(1):189197 Mittova V, Theodoulou FL, Kiddle G, Gmez L, Volokita M, Tal M, Foyer CH, Guy M (2003) Coordinate induction of glutathione biosynthesis and glutathione-metabolizing enzymes is correlated with salt tolerance in tomato
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