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29,179 In chronic high-oxygen exposure or paraquat-induced injury, 180,181 SIRT1 activation can worsen mitochondrial impairment and ROS generation by modulating apoptosis-related proteins and inhibiting Nrf2-mediated antioxidant expression

These include helping to maintain target blood sugar levels and a healthy metabolism, said Sharyn Rossi, PhD, BrightFocus Foundations senior director of neuroscience programs