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As oral metformin slows gastric emptying, this may mean that oral dosing could have a greater impact on reducing postprandial glucose levels by slowing absorption
Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited
This approach enables a refined comparison of gynecologic tumor risks attributable to individual regimens
They do not actually thin the blood
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