Randomised controlled trial (RCT) The gold standard of clinical evidence
In PD, disruptions to the BBB facilitate the spread of Syn within the brain, while Syn aggregates reciprocally worsen BBB damage by instigating immune reactions or compromising BBB integrity, perpetuating a detrimental feedback loop that accelerates PD's pathology
The purity of Ly6G + cells was 99% according to flow cytometry 67
Lamothe J, Khurana S, Tharmalingam S, Williamson C, Byrne CJ, Lees SJ, Khaper N, Kumar A, Tai TC
In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes