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5 Icahn School of Medicine at Mount Sinai, New York, New York, USA
This may have resulted in higher levels of phosphorylation of ACC observed in livers of KO mice (Fig
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Future studies should directly test oral agents such as orforglipron against established injectable therapies in equivalent populations and over longer periods, because current evidence demonstrates efficacy but not definitive comparative durability or safety (Wharton et al., 2023), (Rosenstock et al., 2025)
The future likely holds significant developments
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