Shiraseb F, Mirzababaei A, Daneshzad E, Khosravinia D, Clark CCT, Mirzaei K
Unlike Alzheimers disease, where MGBA-related mechanisms are often discussed in the context of chronic inflammation-associated protein aggregation, the MGBA in PD is more specifically centered on the initiation of -synuclein pathology in the gut and its subsequent retrograde spread along the gutbrain axis [316]
Another dialed it back a bit, but still impressive, showing a 12% weight loss over 52 weeks
Compared to liraglutide (Victoza), another once-daily GLP-1 RA, Ozempic offers similar or slightly better glycaemic control with the convenience of once-weekly dosing
Those include the cost of the drugs, the needles and the side effects