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Future directions Future research should explore combination strategies, including dual and triple therapy regimens pairing tirzepatide with other agents including sodium-glucose cotransporter-2 inhibitors and the non-steroidal mineralocorticoid receptor antagonist, finerenone, which have been shown to offer additive cardiorenal protection alongside GLP-1RAs [35]
The FDA has flagged multiple compounding facilities for similar issues
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Increased water volume
The more we know about how metformin can achieve these effects in the brain's VMH pathway, the more we might be able to unlock new kinds of treatments and not just for controlling blood sugar
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