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GLP-1 medications have multiple different mechanisms in the body that help with diabetes and weight loss, including: Increasing the amount of insulin made by the pancreas , which helps control blood sugar in patients with diabetes Decreasing the amount of excess sugar made by the pancreas , which helps control blood sugar in patients with diabetes Slowing down digestion from the stomach , which results in feeling full for longer after eating Signaling to your brain that you are full after eating , which helps suppress appetite and control cravings Tirzepatide contains an extra mechanism of action that other GLP-1 medications do not, known as GIP (glucose-dependent insulinotropic polypeptide) agonism

She added that pills are also expected to be more affordable and more widely covered by insurance, particularly because some are approved for additional benefits such as heart health

Both compounds exceed this threshold substantially

The frequency of injections varies depending on the specific medication

Long-acting agents seem to have a lower incidence of gastrointestinal adverse effects (166), likely due to tachyphylaxis in gastric emptying with sustained GLP-1R stimulation