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Phosphorylation of glucose by hexokinase is not only required to drive glucose into the glycolytic pathway but also into the pentose phosphate pathway, the major NADPH generating metabolic pathway

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Similar content being viewed by others Introduction Diminished growth hormone (GH) and insulin/insulin-like growth factor-1 (IGF-1) signaling extends lifespan in many laboratory models, including mutations to daf2 in worms 1 , Sch9 in yeast 2 , and Chico in drosophila 3