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Patients evaluating these options should consider not only cost but also how individual genetic and biomarker factors may relate to treatment response

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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials