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(Middle) Upon reaching the tumor site, these nanocarriers exert their therapeutic effects through three primary mechanisms (1): Macrophage Reprogramming, where the delivery of immunomodulators (e.g., TLR agonists) converts tumor-promoting, anti-inflammatory M2 macrophages into tumor-suppressive, pro-inflammatory M1 macrophages
However, comprehensive human pharmacokinetic data remain limited, underscoring reliance on standardized extracts such as SHR-5 with defined rosavin-to-salidroside ratios (99, 101, 102)
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