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A compromised compound mid-study can mean restarting experiments, losing funding cycles, or submitting incomplete data
Furthermore, pragmatic randomized trials directly comparing dose escalation versus maintenance of the 0.5-mg dose with longer-term follow-up are required to establish higher-level evidence on comparative effectiveness and tolerability, including rare AEs
Facial flushing and increased skin warmth [3]
Most clinicians monitor patients for 12 or more weeks before determining an optimal maintenance dose
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