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Participants receiving retatrutide 12 mg weekly achieved an average weight loss of 24.2% of body weight at 48 weeks the largest weight reduction recorded for any anti-obesity medication to date
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This triggers several beneficial effects: it stimulates insulin release when blood sugar levels rise, reduces the amount of glucose the liver produces, and slows down digestion so glucose enters the bloodstream more gradually
256 This apparent contradiction may reflect differences in the extent and context of acinar cell apoptosis
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