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The in vitro experiments were performed using TM3 mouse Leydig cells that were cultured in DMEM/F-12 medium supplemented with 5% horse serum and 2.5% fetal bovine serum, and maintained at 37C under a 5% CO2 atmosphere
Many patients with diabetes mellitus have indications for statin based lipid-lowering therapy because of their high risk of cardiovascular disease as recommended by the American College of Cardiology/ American Heart Association, American Association of Clinical Endocrinologists, American Diabetes Association and the National Lipid Association
doi:10.1189/jlb.3A1015-453RRR 119
We use a microdosing approach, meaning we start patients at a conservative, physiologic dose and increase gradually based on individual response and tolerance
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