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The co-expression of P2X4 and P2X7 receptors enhances the P2X7 receptor-mediated inflammatory response and facilitates P2X7 receptor-mediated IL- 1 production and inflammation through calcium influx (Kawano et al

These findings imply that the off-target effect of sertraline on CatSper in human spermatozoa may affect fertility (Figure 1)

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