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Besides, a shRNA targeting 3-UTR of human ACTL6A transcripts was constructed in the pLKO.1 vector (shACTL6A)
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins
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