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doi: 10.1038/mp.2011.26 8 AnderbergR
Chronic alcohol consumption poses additional concerns, including potential hepatotoxicity, pancreatitis risk (relevant given GLP-1 receptor agonists' association with pancreatitis in susceptible individuals), and interference with diabetes self-management behaviours
Zepbound has also been shown to improve related cardiometabolic markers, including reductions in blood pressure, cholesterol, and visceral fat in people with obesity
This SCFA-mediated reinforcement of intercellular junctions reduces the risk of increased intestinal permeability, commonly referred to as leaky gut, a pathological condition that enables the translocation of luminal antigens and other deleterious molecules into the systemic circulation (170)
Secondly, we employed genetic instruments to proxy trait/drug exposure, which may help reduce confounding bias and prevent reverse causation
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