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The medications work through different mechanisms, produce different magnitudes of effect, and follow different dose escalation curves
Additionally, some novel GLP-1s hold promise for improved tolerability, as evidenced by Structure Therapeutics phase 2 data for GSBR-1290, which demonstrated encouraging results in terms of AEs and discontinuation rates
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However, the side effect profile at equivalent timepoints is actually comparable or better than single-agonist options
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