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Compared with unexposed pregnancies, the GLP-1 RA-exposed group had a higher risk for excess gestational weight gain (risk ratio, 1.32), greater mean birth weight percentile (58.4 versus 54.8 percent), and a higher risk for preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy (risk ratios, 1.34, 1.30, and 1.29, respectively)
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Combination therapies were shown to have stronger benefits regarding most of the measured parameters [including abnormalities in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, markers of systemic inflammation (clear reductions of IL-1 levels), liver inflammation, hepatocellular oxidative stress, hepatic fibrosis and hepatocyte apoptosis] vs
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