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doi: 10.1016/j.ajcnut.2023.03.017 230

About two weeks after the third immunization, one mouse was injected intravenously with 7 g of PV1 sVLP in PBS

330 CAF-derived cytokines (e.g., IL-10, IL-6, CCL2) recruit and polarize macrophages into immunosuppressive M2-TAMs, which secrete TGF- and IL-10, suppressing cytotoxic T-cell responses and facilitating immune escape

Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis