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In a single internally consistent radioligand series measuring inhibition of I-NDP-alpha-MSH binding to membranes from BHK570 cells stably expressing each human receptor, bremelanotide returned Ki values of 0.25 nM at MC4R, 6.4 nM at MC1R, 17 nM at MC5R and 53 nM at MC3R, corresponding to pKi 9.6, 8.2, 7.8 and 7.3 respectively

Think of it as a tool you add when the primary tool needs reinforcement, not something you deploy preemptively

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