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Cold skin, dehydration, and injection into scarred tissue all slow this phase
Rare but serious reactions include chest pain, irregular heartbeat, or paradoxical bronchospasm (worsening wheeze), all of which require immediate medical attention
Current prescribing information includes warnings related to elevated IGF-1, glucose intolerance, fluid retention, malignancy risk, hypersensitivity, and injection-site reactions. A complete safety discussion belongs in a separate article, but these limitations are essential when interpreting potential benefits
One particularly eye-opening study focused on people with peripheral artery disease (PAD)
Komaroff AL, Dantzer R
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