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The lack of sufficient Estrogen is often addressed in Deca only cycles by adding an adjunct anabolic steroid that aromatizes into Estrogen or Estrogen analogs

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Tell your doctor if you take any other medications, including prescribed, over-the-counter, or herbal types, particularly: You must use contraception while taking the Wegovy pill because it is not known whether semaglutide is safe during pregnancy

After reading the first section you should already understand why, but lets recap it here