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Researchers found that overweight adults without diabetes lost an average of 16% of body weight over the course of 68 weeks when they received a once-weekly subcutaneous 2.4 mg semaglutide injection

The nasal mucosa is highly vascularized and offers a large surface area, but peptide absorption there is also limited by mucociliary clearance, local peptidase activity, and the molecules size and charge

Unresolved questions and future directions Currently, despite promising prospects in preclinical models, targeting glutamine metabolism faces challenges in clinical trials due to inherent heterogeneity in glutamine metabolism within tumor cells and immune cells, as well as its complex impact on immune responses