However, chronic exposure can promote stable increases in these metabolic phenotypes, as evidenced by our resistant organoid models (Extended Data Fig
Its deeply tied to: Cortisol levels (stress hormone) Estrogen/testosterone ratios Insulin sensitivity and blood sugar regulation Age and inflammation When you begin to lose weight, your body often sheds subcutaneous fat first especially in areas that arent hormonally protected. But belly fat stays because your body thinks you might need it later
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