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Naltrexone/bupropion (Mysimba) is licensed for adults with BMI 30 kg/m (or 27 kg/m with weight-related comorbidities)

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About fifteen percent of patients are clinical non-responders to semaglutide, defined as patients who have lost less than five percent of body weight by week twelve at the therapeutic dose

Here's the honest answer: most researchers who report 'non-response' to 5-Amino-1MQ never had a peptide problem