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Relationship of Interleukin-1 Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial
Nrf2 is the principal transcription factor in charge of protecting cells from oxidative stress through the regulation of cytoprotective genes, including the antioxidant GSH pathway, that controls GSH homeostasis by affecting de novo synthesis
In addition, the expression levels of CENPT were increased by treatment with GSH, forming a CENPT-GCLC-GSH positive feedback loop to enhance the progression of RCC
& Bouvet, P
C.SchneewindO.et al (2006)
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