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Plasma lipids are also considered important risk factors and the GLP-1RAs appear to reduce postprandial triglycerides (again by an unknown mechanism), and apolipoprotein (Apo) B48 may be reduced in parallel, suggesting that fat absorption is reduced

The study included dose escalation as recommended by the manufacturer, beginning with a quarter of the full dose (naltrexone 8 mg/bupropion 90 mg once daily) at week 1 and gradual increment weekly to the full dose (naltrexone 32 mg/bupropion 360 mg in 2 divided doses) at week 4

Table 2 Summary of the main pediatric studies on the use of SGLT2 inhibitors

Those with heart disease or uncontrolled hypertension have an increased risk as some peptides can increase blood pressure or cause cardiovascular stress