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The other side is renewal: fasting, autophagy, cellular cleanup, clearing out damaged cells

Inflammation plays a dual role in tissue healing

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While genetic knockout substrains show genotypic and phenotypic pathways for mitigating loss of a target gene (ie., evolved similar phenotypes or secondary mutations in off-target genes), gene overexpression is perhaps more complicated in that the amount of target protein expression is highly variable, alongside the possible genome-wide effects of the mutation

"MOTS-c reduces myostatin and muscle atrophy signaling." American Journal of Physiology-Endocrinology and Metabolism