semaglutide and fasting Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet Formulation | Diabetes Therapy Semaglutide for Weight Loss: What

Ohishi J, Aoki M, Nabeshima K, Suzumiya J, Takeuchi T, Ogose A, et al

22 , 532541.e538 (2024)

Why it matters: Preserves lean muscle mass and bone density Supports metabolic rate Improves satiety without worsening nausea Supports immune function and recovery Protein targets during active weight loss A practical, evidence-aligned approach: 1.2 to 1.6 grams per kilogram of ideal body weight per day during active weight reduction Or an absolute target of 80 to 120 grams per day, which many people find easier to follow For individuals at risk of sarcopenia, aim for at least 1.3 grams per kilogram per day

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Hsu et al used the TriNetX platform to study the association between semaglutide use and the incidence of NAION and found that it was associated with an increased risk in patients with diabetes at the 2-, 3-, and 4-year timepoints but not within 1 year of GLP-1 RA initiation