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Western blot results demonstrated that the expression of the odonto/osteogenic proteins (DMP1, COL-I, ALP, RUNX2, OSX, DSP and OCN) was significantly decreased in IGF-1 treated SCAPs accompanying with the over-expression of hsa-let-7c , in which the expression of RUNX2 and DSP kept reducing from day 3 to day 7, and the expression of DMP1, COL-I, ALP, OSX and OCN obviously decreased at day 7 (Fig
Moreover, retinal protection was achieved without affecting systemic blood glucose levels in this study, suggesting the protective effects of GLP-1 are independent of blood glucose or insulin [80]
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