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Lastly, coagulation defects in cirrhosis, manifesting as petechiae, ecchymoses, or mucosal bleeding, are due to thrombocytopenia and other hemostasis abnormalities, like those seen in hematologic disorders and anticoagulant therapy for thrombotic diseases
Hemolysis: Destruction of red blood cells if a large volume of hypotonic solution is injected IV
Although EMPEROR-R enrolled patients with and without type 2 diabetes, the primary outcome of the trial (a composite of CV death and hospitalization for HF) was almost identical in both groups, suggesting that the different population didnt affect the results, at least for the primary outcome
The MHRA update is simply a reminder that powerful drugs require powerful vigilance, and until we have larger, long-duration real-world safety data, clinicians should err on the side of specificity in monitoring and patients should be taught exactly what to look for. Hector Perez, MD
5ae), indicating that no interaction with GLP-1R was involved
