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Maternal polymorphisms of folate pathway genes and risk of congenital heart defects in the DS child Several congenital complications are observed in individuals with DS (for a review see Weijerman and de Winter, 2010), some of which potentially affected by impaired maternal one-carbon metabolism and consequent epigenetic changes during embryogenesis or impaired requirements of DNA precursors for cellular divisions
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10.3969/j.issn.1006-2157.2015.03.008 130 ZhouS.ChenS.XieW.GuoX.ZhaoJ
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