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It has been shown that in patients with type 2 diabetes mellitus (T2DM) the response to the incretin effect is altered as a result of a severe defect in the sensitivity for GIP in the cells [4] and a reduction in food-induced GLP-1 secretion [5, 6]
10.1038/nn.2172 197 ShieldsS
10.1038/ng1622 112 WarcholM
Both partners engage the NF-kB / cytokine axis via related mechanisms, which makes it hard to resolve their individual contributions
poison control centers see steep rise in exposure calls tied to popular weight-loss drugs Poison control experts say calls related to GLP-1 weight-loss drugs like Wegovy and Zepbound are rising, with symptoms like nausea, vomiting and abdominal pain
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