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Talk openly with your prescriber Severe constipation, abdominal pain, vomiting or inability to pass gas or stool need medical attention.Harvard Health+1 Sometimes the solution is as simple as: adjusting the dose or how quickly its increased adding or changing a laxative regimen ruling out other causes of symptoms You should never feel like you have to tough it out alone

Lombardi, S

The results of a clinical study further confirmed this observation by showing that patients with nonmetastatic lung cancer harbored loss-of-function mutations in SDH5 128

2024 Mar;119(3):599-627.