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Beckers Hospital Review
In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week
No dose-ranging study has established a human oral dose for this compound, so the high oral numbers circulate as community and vendor convention rather than as published clinical figures
Research in animal models indicates that elevated NNMT expression is associated with reduced levels of the glucose transporter GLUT4
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