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For patients requiring further glycaemic control, the dose can be increased to 2 mg once weekly after at least 4 weeks at the 1 mg dose

GLP-1 Drugs and Effects on Consumers The body produces the GLP-1 hormone naturally as part of its system for managing blood sugar

doi: 10.1542/peds.2010-0433 335 SecherTKassemSBenamarMBernardIBouryMBarreauFet al

Liraglutide , administered once daily, demonstrates nausea rates of approximately 1826% at diabetes doses (Victoza) and up to 40% at the higher dose used for weight management (Saxenda), according to UK SmPCs

This aberrant SNO can lead to conformational changes and misfolding of the proteins that affect their functions [167]