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doi: 10.2165/00007256-200030030-00002
Cholinergic hypothesis states that the degeneration of basal forebrain neurons in AD patients leads to dysfunction and death of cholinergic neurons in the forebrain, followed by extensive presynaptic denervation occurs, and the loss of specific subtypes of acetylcholine receptors, leading to cognitive decline in AD patients (39)
On D4, medium was replaced with StemPro-34 SFM medium as a base containing the following: 2 mM GlutaMax (Gibco), 25 ng/mL bFGF, 100 ng/mL SCF and 80 ng/mL VEGF
doi: 10.3389/fendo.2021.735019 79 LazzaroniEBen NasrMLoretelliCPastoreIPlebaniLLunatiMEet al
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