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GLP-1 (Semaglutide): Reduces appetite Slows gastric emptying Increases satiety Supports sustainable calorie reduction Average weight loss: Up to 15% in 68 weeks (NEJM 2021) GLP-1 + GIP (Tirzepatide): GLP-1 + GIP synergy boosts insulin sensitivity Enhances metabolic balance Further suppresses appetite and cravings Average weight loss: Up to 21% in 72 weeks (SURMOUNT-1) Compounded vs

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That is a substantial monotherapy effect for an appetite-axis-only agent, and it established cagrilintide as a credible weight-management candidate on its own