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At the molecular level, The compound has been shown to reduce production of tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and other pro-inflammatory cytokines

A pooled analysis of six randomized placebo-controlled trials (n=618) indicated that responses at 4 weeks may predict response at 6-9 weeks, although another pooled analysis of open-label data (n=338) suggests that the probability of a robust response to atomoxetine [40% decrease in ADHD-Rating Scale (ADHD-RS) scores] may continue to increase beyond 6-9 weeks

[84] demonstrated that in colorectal cancer, suppression of the MondoATXNIP axis promotes glucose uptake and glycolysis, leading to the induction of highly glycolytic, Th17-like Tregs

Animal models have demonstrated no significant toxicity even at high doses, and the peptide appears to have cytoprotective (cell-protecting) properties