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L-carnitine is primarily synthesized in the liver and transported via the bloodstream to cardiac and skeletal muscle, which rely on L-carnitine for fatty acid oxidation yet cannot synthesize it (8)
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Plasma nonesterified fatty acid (NEFA) was measured using a NEFA-C assay kit (WAKO, Osaka, Japan)
PMID: 148 HadadiETaylorWLiXMAslanYVilloteMRivireJet al
In Phase I clinical trials, PGN-EDO51 showed good safety, tolerability, and efficacy, and Phase II trials are ongoing
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