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These compounds work through entirely different mechanisms, making direct comparison difficult

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As methionine, ingested as protein in the diet, is the only source of homocysteine, it would be expected that food intake would cause increased concentrations of homocysteine in plasma

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[1] [2] While originally developed for type 2 diabetes management under the brand name Ozempic, a higher-dose formulation marketed as Wegovy received FDA approval specifically for weight management in 2021