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Go to the amelanotic melanoma topic page An irregularly marginated red lesion on the arm - an amelanotic melanoma (AM-patient1) Dermoscopy of an amelanolic melanoma showing non-specific blood vessels, structureless areas, multiple colours and only occassional brown dots (AM-patient1) An irregularly pigmented lesion with a white nodule at the apex - an amelanotic melanoma (AM-patient2) Irregular polymorphous vessels and a white structureless area in the apex of an amelanotic melanoma (AM-patient2) Polymorphous vessels and a pink-grey structureless area - an amelanotic melanoma (AM-patient2) A pink-brown macule with a white central area - an amemanotic melanoma (AM-patient3) Dermoscopy showing grey-brown clods and polymorphous vessels - an amelanotic melanoma in situ (AM-patient3) Dermoscopy showing grey-brown clods and polymorphous vessels - an amelanotic melanoma in situ (AM-patient3) Dermoscopic image of an eroded plaque on the arm - histology showed an amelanotic melanoma (AM-patient4) An eroded plaque on the arm - histology showed an amelanotic melanoma (AM-patient4) Amelanotic nodular melanoma Amelanotic nodular melanoma Ulcerated nodular melanoma Amelanotic melanoma arising within pigmented melanoma Amelanotic melanoma Amelanotic nodular melanoma Melanoma of nail unit Ungual melanoma Amelanotic subungal melanoma - a red lesion arising from the nail fold that has produced destruction of the nail plate Amelanotic superficial spreading melanoma in situ Amelanotic melanoma Amelanotic melanoma Amelanotic melanoma Amelanotic nodular melanoma L arm melanoma

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Thus, these data suggest that late-life targeting of IGF-1R signaling can recapitulate effects observed in genetic models of constitutive IGF-1R haploinsufficiency on lifespan

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