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(2015) 5:a022863

Others may be difficult to avoid, including brain injury or environmental factors

This is consistent with the known side effect profile of GLP-1 medications, where headaches appear in a meaningful minority of patients during dose initiation and escalation phases

Having cleared the hurdle as a treatment for diabetes, the FDA then approved semaglutide, marketed as Wegovy, for obesity in 2021, and then in Europe the following year