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She said several factors explain their rapid adoption: They significantly reduce appetite and help people eat less without constant hunger Some are FDA-approved for chronic weight management in people who meet eligibility criteria There is growing recognition in healthcare that obesity is a chronic disease, not simply a willpower issue, and may require long-term medical treatment Their popularity also reflects strong public awareness and patient demand, though cost, access, and insurance coverage remain major barriers for many people, Araghi said

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And for everyone, the unfavorable shift in body composition (less muscle, proportionally more fat) creates what researchers call sarcopenic obesity, arguably the worst metabolic phenotype

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doi:10.1001/jamapsychiatry.2024.4789