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Lixisenatide, a structurally modified derivative of exendin-4, addresses some of these limitations by offering a longer half-life of approximately 3 h, thereby permitting once-daily dosing (Leon et al., 2017)

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Reduced caloric intake improves insulin sensitivity, reduces liver fat, and lowers inflammatory markers

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For a 70 kg person, that yields 1.05 to 2.1 mg per day, consistent with the flat-dose ranges below