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The strongest direct evidence here is for retatrutide alone (Phase 2 and Phase 3 trial data)
Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS et al
These include diet, malabsorption, and some medical conditions
A 2024 meta-analysis in JCEM, Inositol for Polycystic Ovary Syndrome: Systematic Review and Meta-analysis , found selective metabolic benefits in some contexts, which does not validate MIC injections for universal weight loss
The full effectiveness of supplements is still being studied, and the FDA does not regulate supplements as closely as medications
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