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To date, studies have reported minimal adverse effects at typical research-level dosages

It does not alter or affect skin structure or function

For users who have reacted badly or want similar benefits with less risk, PDRN is gaining traction as a gentler regenerative active

Inhibits inflammation and oxidative stress, possibly acting as an antioxidant68

Studies show it may be well tolerated in higher doses of 700mg three times a day, as well, with few to no adverse effects when taken as an oral supplement (but we dont recommend taking more than what a supplement manufacturer instructs).31 That's not to say that adverse effects aren't out of the question