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In -cells, GLP-1(936) activates GLP-1R, increasing cAMP and activating PKA and CREB to promote insulin secretion

Injection site reactionssuch as redness, itching, or mild discomfort at the injection siteare typically minimal but can occur

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Finally, most of the included trials recruited patients from the USA, Europe, and some Asian countries, which limits the generalizability of the results across all ethnic groups