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Interleukin-1 beta (IL-1) is a pro-inflammatory cytokine involved in immune responses, inflammation, and cell death

Hair loss has been documented with various GLP-1 and GIP/GLP-1 agents, though causality and whether this represents a true class effect remain unproven

30 October 2022

Some phenotypes plausibly need a slower-than-label climb: lighter bodies (higher exposure per milligram), a history of severe GLP-1 gut intolerance, a high baseline heart rate, or a lean, low-reserve build

In SURMOUNT-1, around 4 to 7% of people on tirzepatide stopped the medication because of side effects, compared with 2.6% on placebo